CD133-targeted Gene Transfer Into Long-term Repopulating Hematopoietic Stem Cells
نویسندگان
چکیده
منابع مشابه
CD133-targeted gene transfer into long-term repopulating hematopoietic stem cells.
Gene therapy for hematological disorders relies on the genetic modification of CD34(+) cells, a heterogeneous cell population containing about 0.01% long-term repopulating cells. Here, we show that the lentiviral vector CD133-LV, which uses a surface marker on human primitive hematopoietic stem cells (HSCs) as entry receptor, transfers genes preferentially into cells with high engraftment capab...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2015
ISSN: 1525-0016
DOI: 10.1038/mt.2014.173